DNA Codon Recognition by a Cubane Wire: In Silico Approach

DNA codons, consisting of triplet nucleotides (NTs), could play important roles for RNA transcription and protein translation in living systems. Therefore, their recognition be seen diagnosis therapy purposes. Based on sequence formations Adenine (A), Guanine (G), Cytosine (C) Thymine (T) NTs, 64 codons were investigated this work regarding complexation with a molecular cubane (CUB) wire. To achieve aim, each singular CUB optimized to prepared docking processes complex formations. Hence, complexes codon-CUB docked see the potency wire versus codons. Interestingly, obtained scores indicated that specifically which G-rich A-rich triples more favorable comparison other C-rich T-rich Moreover, results not pure G but GAG codon was most one recognized by However, T worst such The remarkably process from very much specified best among all